Haseeb Anwar
Department of Physiology, Government College University, Pakistan
Title: Comparison of local with imported probiotic species regarding oxidative stress, liver enzymes and hormonal dynamics in rats model
Biography
Biography: Haseeb Anwar
Abstract
The gastrointestinal tract is a multifaceted ecosystem host to an assorted and highly evolved microbial community comprised of different microbial species. The interactions that occur between this multifarious microbial community and the host have become the focus of scientific research due to involvement of deficient or compromised microflora in the increased occurrence of illnesses. Probiotics are composite of these live microbial preparations which can be used as supplementation to boost or alter the gut microbial ecology. However the viability and adaptation of these supplemented microbial population is of great concern. Current Project is designed to investigate the efficacy of locally prevailing microbial species (LP group) compared with the commercially available probiotic supplements (IP group) which are imported in nature. The significance was tested regarding the oxidative stress markers, liver enzymes, cholesterol profile and hormonal dynamics in albino wistar rats model. Total oxidant status decreased significantly (P≤0.05) in the LP group as compared to IP and Control (Cont). The TAC was improved (P≤0.05) in LP as compared to the IP group. Liver enzymes AST, ALT and total cholesterol decreased (P≤0.05) in LP group as compared to IP. Growth and luteinizing hormone decreased (P≤0.05) in IP as compared to LP. The use of local probiotic species shows promising results regarding the reduction in oxidative stress, liver enzymes and cholesterol over the imported probiotic species.