Hyunsook Kim
Hanyang University, Republic of Korea
Title: Anti-obesity effect of kefi r-derived exopolysaccharides
Biography
Biography: Hyunsook Kim
Abstract
Poster Presentation:
Physiological properties of water-soluble exopolysaccharides (EPS) and their remained residues after removal of EPS from probiotic kefir were determined in C57BL/6J mice fed a high-fat diet. EPS solutions had rheological properties and lower viscosity than β-glucan (BG). EPS significantly suppressed the adipogenesis of 3T3-L1 preadipocytes in a dose-dependent manner. Mice were fed high-fat (HF) diets containing 5% EPS, 5% -glucan (BG, viscous soluble fi ber), 8% residues, or microcrystalline cellulose (control) for 4 weeks. EPS supplementation significantly reduced HF diet-induced body weight gain, adipose tissue weight, and plasma VLDL-cholesterol concentration compared with the control (p<0.05). The residues and BG also significantly reduced body weight gain, but reduction of adipose tissue weight did not reach statistical significance, suggesting anti-obesity effect of EPS is due to viscosity as well as possible additional factor. EPS supplementation significantly enhanced abundance of genera Akkermansia in feces. These data indicate that EPS has significant anti-obesity effects, which is possibly involved in altered intestinal microbiota.