Riadh Ben Salah
University of Sfax
Tunisia
Title: Effect of a probiotic Lactobacillus plantarum TN8 on induced colitis, liver and kidney tissue in Wistar rats
Biography
Biography: Riadh Ben Salah
Abstract
This study aimed to investigate the potential effects of an oral treatment involving a newly isolated probiotic Lactobacillus plantarum TN8 strain on 2-4-6-trinitrobenzen sulfonic acid (TNBS)-induced colitis in Wistar rats. The performance and effects of the probiotic treatment was evaluated using a series of histological, biophysical and biochemical analyses. The results showed that the treatment with the L. plantarum TN8 strain reduced weight loss (25% increases in body weight gain), diarrhea, colonic mucosal inflammation and colon shortening. The treated rats were also noted to undergo a significant decrease in total cholesterol from 1.86-1.3 mmol/l (for control rats) and triglyceride (TG) from 2.09-1.23 mmol/l (for control rats). Furthermore, the findings showed that the high density lipoprotein (HDL)-cholesterol underwent an increase from 0.95 to 1.02 mmol/l. The findings from histological studies showed that the architecture of the liver and kidney tissues of the TN8-treated rats was restored back to the normal status observed for the control groups. Overall, the results suggest that the L. plantarum TN8 could open new promising opportunities for the development of efficient, safe and cost-effective agents for the prevention or alleviation of several intestinal pathologies.